Why the study?
Do early changes in surface ECG predict the development of torsades de pointes in patients treated with almokalant?
Population
12 patients treated with almokalant
Comparison
Almokalant infusion vs Almokalant infusion
Design
Case-control
Follow-up
40 minutes
Authors
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Early QTtop prolongation was associated with TdP on almokalant; hypothesis-generating for ECG-based prediction pending prospective validation.
Do early changes in surface ECG predict the development of torsades de pointes in patients treated with almokalant?
A rapid and pronounced increase in QTtop duration, interlead QT dispersion, and intralead QT variability early during almokalant infusion predicts the development of torsades de pointes.
Svernhage et al. (1998) studied this question.
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