Key result
A history of drug-induced Torsades de Pointes was associated with increased baseline repolarization heterogeneity (ERD30% 44 vs 35 ms, P=0.02) and sotalol-induced terminal T wave prolongation.
Why the study?
Do computerized parameters of ventricular repolarization at baseline and after sotalol challenge characterize individuals with a history of drug-induced Torsades de Pointes?
Case-Control (n=33)
Do computerized parameters of ventricular repolarization at baseline and after sotalol challenge characterize individuals with a history of drug-induced Torsades de Pointes?
Absolute Event Rate: 44% vs 35%
p-value: p=.02
Computerized ECG analysis of repolarization heterogeneity at baseline and after sotalol challenge can help identify patients susceptible to drug-induced Torsades de Pointes.
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May aid identification of drug-induced TdP susceptibility; leaves open prospective validation before clinical use.
Couderc et al. (2008) conducted a case-control in Drug-induced Torsades de Pointes (n=33). History of drug-induced Torsades de Pointes vs. No history of drug-induced Torsades de Pointes was evaluated on Repolarization heterogeneity of the early part of the T wave (ERD30%) at baseline (p=.02). A history of drug-induced Torsades de Pointes was associated with increased baseline repolarization heterogeneity (ERD30% 44 vs 35 ms, P=0.02) and sotalol-induced terminal T wave prolongation.
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