What question did this study set out to answer?

To investigate cardiac output and left ventricular function responses during exercise in older men.

February 1, 1993Canadian Journal of Physiology and Pharmacology

Cardiac output and left ventricular function in response to exercise in older men

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Why the study?

What is the cardiovascular and left ventricular functional response to submaximal and strenuous exercise in older men?

Population

108 older men, mean age 63 years

Comparison

Incremental treadmill test and incremental… vs Resting state and historical data from younger…

Design

Cross-sectional

Authors

STScott ThomasUniversity of Notre Dame DPDonald H. PatersonPreventive Cardiology DCDavid A. CunninghamTexas A&M University

Discussion

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Implication

Supports preserved LV performance during exercise in older men; challenges prior reports of marked age-related decline but requires longitudinal confirmation.

Key Points

To investigate cardiac output and left ventricular function responses during exercise in older men.
Examined 96 men with a mean age of 63 during an incremental treadmill test.
Measured cardiac output using CO2 rebreathing and left ventricular volumes via radionuclide angiocardiography in a subset of 12 subjects.
Analyzed cardiovascular responses during both submaximal and strenuous exercise.
Cardiac output during treadmill exercise was approximately 10% lower than in younger samples.
At near-maximal exercise, cardiac output reached 15 L.min-1 with stroke volume plateauing at 95 mL.
Ejection fraction increased from 66% at rest to 76% at peak exercise, indicating effective left ventricular function.

Structured PICO

What is the cardiovascular and left ventricular functional response to submaximal and strenuous exercise in older men?

Population

108 older men (96 evaluated during incremental treadmill test, 12 evaluated during incremental supine exercise), mean age 63 years

Intervention

Incremental treadmill test and incremental supine exercise

Comparator

Resting state and historical data from younger samples

Outcome

Cardiovascular response including cardiac output (Q), stroke volume (SV), arteriovenous O2 difference, and left ventricular volumes/ejection fractionsurrogate

Older men show only small losses in cardiovascular response and left ventricular performance during light through strenuous exercise, challenging some prior reports of significant age-related decline.

Cite This Study

Thomas et al. (1993) studied this question.

synapsesocial.com/papers/6a7588b83c1d3f13c2dd7ecc https://doi.org/10.1139/y93-019

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Implication

Supports preserved LV performance during exercise in older men; challenges prior reports of marked age-related decline but requires longitudinal confirmation.

Cardiac output and left ventricular function in response to exercise in older men

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiac output and left ventricular function in response to exercise in older men

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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