Key result
Older age correlates with higher ventricular volumes and lower EF during peak exercise.
Why the study?
The effects of age and sex on exercise left ventricular volume indexes and ejection fraction in normal subjects were not well characterized.
How do age and sex influence left ventricular volumes and ejection fraction during upright exercise in normal subjects?
Cross-Sectional (n=35)
How do age and sex influence left ventricular volumes and ejection fraction during upright exercise in normal subjects?
Age and sex significantly influence left ventricular volumes, ejection fraction, and exercise capacity during maximal upright exercise in healthy individuals, which should be accounted for when interpreting exercise imaging.
Supports age- and sex-adjusted reference values for exercise echocardiography; leaves open validation in clinical populations.
To determine the effects of age and sex on exercise left ventricular volume indexes and ejection fraction, a cross-sectional study was performed in 18 young volunteers (nine men and nine women) and in 17 older volunteers (nine men and eight women) without evidence of coronary artery disease by exercise electrocardiographic and thallium-201 criteria. All subjects performed a multistage maximal upright exercise with measurements of maximal oxygen consumption and heart rate; left ventricular ejection fraction and absolute volume indexes were measured at rest and during submaximal and maximal exercise using equilibrium radionuclide ventriculography. At rest, no effect of age or sex on any parameter was observed. At peak exercise, an age-related increase in mean blood pressure, end-diastolic and end-systolic volume indexes, and decrease in ejection fraction, cardiac index, heart rate and oxygen consumption were noticed. Sex had a significant effect on maximal workload, maximal oxygen consumption and ejection fraction.
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Younis et al. (1990) conducted a cross-sectional in Healthy volunteers without coronary artery disease (n=35). Age and sex was evaluated on Left ventricular volume indexes and ejection fraction during upright exercise. Older age and sex significantly influenced cardiovascular parameters at peak exercise, with age increasing ventricular volumes and decreasing ejection fraction, and sex affecting maximal workload.
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