August 6, 2013PLoS ONEOpen Access

Mesenchymal-to-Endothelial Transition in Kaposi Sarcoma: A Histogenetic Hypothesis Based on a Case Series and Literature Review

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Population

15 cases of Kaposi sarcoma diagnosed during 2000-2011

Design

Case_series

Authors

SGSimona GurzuUniversitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș DCDiana CiorteaUniversitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș TMTeodora MunteanuUniversitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Discussion

Member takes

Implication

May support myofibroblastic reclassification of Kaposi sarcoma; hypothesis-generating from single case report and requires validation.

Structured PICO

Population

15 cases of Kaposi sarcoma diagnosed during 2000-2011

Intervention

Immunophenotypic analysis of c-Kit, SMA, CD34, CD31, VEGF, COX-2, and CD105

Outcome

Correlation of clinicopathological features with immunoexpression of various markerssurrogate

Kaposi sarcoma exhibits features of mesenchymal-to-endothelial transition and myofibroblastic-like differentiation, indicating it is not a pure vascular tumor.

Cite This Study

Gurzu et al. (2013) studied this question.

synapsesocial.com/papers/6a7588d33c1d3f13c2dd7ede https://doi.org/10.1371/journal.pone.0071530

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Mesenchymal-to-Endothelial Transition in Kaposi Sarcoma: A Histogenetic Hypothesis Based on a Case Series and Literature Review

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mesenchymal-to-Endothelial Transition in Kaposi Sarcoma: A Histogenetic Hypothesis Based on a Case Series and Literature Review

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider