Why the study?
Altered thyroid function and elevated NT-proBNP are prognostic in AMI, but whether fT3 and NT-proBNP predict long-term outcomes after PCI needed investigation.
Do free triiodothyronine (fT3) and NT-proBNP predict long-term outcomes in patients with acute myocardial infarction undergoing percutaneous coronary intervention?
Do free triiodothyronine (fT3) and NT-proBNP predict long-term outcomes in patients with acute myocardial infarction undergoing percutaneous coronary intervention?
Low fT3 combined with elevated NT-proBNP is a strong independent predictor of poor long-term prognosis in patients with AMI undergoing PCI.
Low fT3 independently predicted higher MACE risk after AMI PCI; supports prospective validation of combined fT3-NT-proBNP stratification before clinical use.
BACKGROUND: Altered thyroid function and increased N-terminal pro-B-type natriuretic peptide (NT-proBNP) are prognostic factors in acute myocardial infarction (AMI). The study aims to investigate whether free triiodothyronine (fT3) and NT-proBNP are prognostic factors for long-term outcomes in patients with AMI undergoing percutaneous coronary intervention (PCI). METHODS: This was an observational, prospective, single-center study of consecutive patients enrolled at Fuwai Hospital between January, 2013 and December, 2013. The patients were divided into two groups according to fT3 levels: low fT3 (<2.5 pg/mL) and normal fT3 (2.50-4.09 pg/mL). The primary outcome of this study was the incidence of major adverse cardiovascular events (MACEs). RESULTS: 7.8%, P<0.001). Univariable Cox proportional hazards regression analyses showed that NT-proBNP >802.7 pg/mL [hazard ratio (HR) =5.063, 95% confidence interval (CI): 3.176-8.071, P<0.001] and fT3 <2.5 pg/mL (HR =3.867, 95% CI: 2.646-5.651, P<0.001) were the strongest predictors of MACEs. After adjustment for traditional risk predictors, fT3 <2.5 pg/mL (HR =2.570, 95% CI: 1.653-3.993, P<0.001) was one of the most important independent predictors of MACEs. Patients with NT-proBNP ≤802.7 pg/mL and fT3 ≥2.5 pg/mL had the best prognosis, while patients with NT-proBNP >802.7 pg/mL and fT3 <2.5 pg/mL had the worst outcomes (P<0.001). CONCLUSIONS: Low fT3 is a strong predictor of poor prognosis after AMI. The fT3+NT-proBNP combination might be a valuable predictor of the long-term outcomes of PCI after AMI.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: