Why the study?
Does inadequate treatment (marginal excision alone) increase the risk of metastases compared to adequate treatment in patients with soft tissue sarcoma?
Population
375 patients with soft tissue sarcoma of the extremities and the trunk wall
Comparison
Inadequate treatment (marginal excision alone) vs Adequate treatment
Design
Cohort
Authors
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Does not support re-excision after marginal margins to avert metastases; leaves open whether local recurrence drives distant spread in sarcoma.
Does inadequate treatment (marginal excision alone) increase the risk of metastases compared to adequate treatment in patients with soft tissue sarcoma?
Local recurrence is of minor importance for the development of metastases in soft tissue sarcoma, suggesting that increased local recurrence in metastatic tumors reflects the primary tumor's aggressiveness rather than causing distant spread.
Gustafson et al. (1991) studied this question.
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