Key result
Tumor size, necrosis, and vascular invasion were strong prognostic factors for metastasis in soft tissue sarcoma, identifying two thirds of patients with a 5-year MFSR of 0.8 and one third with 0.3.
Cohort (n=508)
Yes
Tumor size, tumor necrosis, and vascular invasion are strong prognostic factors for metastasis in soft tissue sarcoma, and local recurrence appears to be a marker of risk rather than a direct cause of metastasis.
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May refine metastatic risk stratification in soft tissue sarcoma; leaves open impact on management pending prospective validation.
Pelle Gustafson (1994) conducted a cohort in Soft tissue sarcoma (STS) of the extremity and trunk wall (n=508). Tumor size, necrosis, and vascular invasion were strong prognostic factors for metastasis in soft tissue sarcoma, identifying two thirds of patients with a 5-year MFSR of 0.8 and one third with 0.3.
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