Key result
Initial prognostic factors for metastasis in malignant fibrous histiocytoma lost predictive value after 2 years, with annual metastasis risks in high- and low-risk groups converging to <0.1.
Population
338 patients with malignant fibrous histiocytoma of the extremities or the trunk wall
Design
Cohort
Follow-up
median 7 years
Authors
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Supports tailoring MFH surveillance intensity to the first 2 years; leaves open optimal long-term monitoring strategies.
Cohort (n=338)
Yes
The predictive value of initial prognostic factors for metastasis in malignant fibrous histiocytoma is largely limited to the first 2 years of follow-up.
Engellau et al. (2004) conducted a cohort in Malignant fibrous histiocytoma (MFH) of the extremities or the trunk wall (n=338). Initial tumor-related prognostic factors (e.g., necrosis, local recurrence, tumor depth) vs. Low-risk groups / absence of factors was evaluated on Metastases. Initial prognostic factors for metastasis in malignant fibrous histiocytoma lost predictive value after 2 years, with annual metastasis risks in high- and low-risk groups converging to <0.1.
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