Why the study?
Does adrenomedullin infusion increase regional vascular blood flow differently in healthy subjects compared to patients with chronic heart failure?
Population
10 healthy subjects and 18 patients with chronic heart failure for primary analysis; 11 healthy subjects and…
Comparison
Adrenomedullin infusion vs Healthy control subjects
Follow-up
Acute observation (>60 minutes post-infusion)
Authors
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Does not support ADM vasodilator use in CHF; leaves open mechanisms and clinical relevance.
Does adrenomedullin infusion increase regional vascular blood flow differently in healthy subjects compared to patients with chronic heart failure?
Adrenomedullin produces potent, nitric oxide-dependent vasodilation in normal humans, but this effect is significantly blunted in patients with chronic heart failure.
Nakamura et al. (1997) studied this question.
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