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This research aims to explore variations in nasopharyngeal microbiota profiles based on lytA-PCR status in adults with pneumococcal pneumonia.

August 7, 2026PneumoniaOpen Access

Nasopharyngeal microbiota profiles and lytA-PCR status in adult pneumococcal pneumonia: distinct microbial communities and diagnostic implications

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This research aims to explore variations in nasopharyngeal microbiota profiles based on lytA-PCR status in adults with pneumococcal pneumonia.
Prospective observational study of adults hospitalized with pneumonia.
Nasopharyngeal samples collected for lytA-PCR quantification and 16S rRNA gene sequencing before treatment.
Microbiota diversity analyzed using metrics like alpha and beta-diversity, and differential abundance assessed with ALDEx2.
Of 38 patients, 63% were lytA-positive and 37% were lytA-negative.
Beta-diversity revealed significant differences in microbiota composition linked to lytA status.
Streptococcus spp. enriched in lytA-positive samples, while Corynebacterium and Dolosigranulum were predominant in lytA-negative samples.

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Observational study examines distinct nasopharyngeal microbiota in adults with pneumococcal pneumonia, highlighting diagnostic potential.

Dietl et al. (2026) studied this question.

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