December 1, 1993Journal of Clinical InvestigationOpen Access

Impairment of cardiac function and energetics in experimental renal failure.

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Why the study?

Does experimental renal failure impair cardiac function and energetics in a rat model?

Population

Rat model of experimental renal failure (5/6 nephrectomy)

Comparison

Experimental renal failure (5/6 nephrectomy) vs Pair-fed sham operated control group

Design

Preclinical

Follow-up

4 weeks

Authors

ARA. E. G. RaineUppsala University ASAustin M. SeymourLos Alamos National Laboratory ARAnn F.C. RobertsJohn Radcliffe Hospital

Discussion

Member takes

Implication

Provides mechanistic insight into cardiorenal energetics in rats; leaves open translation to human disease and therapies.

Structured PICO

Does experimental renal failure impair cardiac function and energetics in a rat model?

Population

Rat model of experimental renal failure (5/6 nephrectomy)

Intervention

Experimental renal failure (5/6 nephrectomy)

Comparator

Pair-fed sham operated control group

Outcome

Cardiac function (cardiac output) and energetics (phosphocreatine levels, phosphocreatine to ATP ratio)surrogate

Experimental renal failure in rats impairs cardiac function and energetics, increasing susceptibility to ischemic damage.

Cite This Study

Raine et al. (1993) studied this question.

synapsesocial.com/papers/6a758ba89c92392688b232bf https://doi.org/10.1172/jci116916

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Impairment of cardiac function and energetics in experimental renal failure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Impairment of cardiac function and energetics in experimental renal failure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider