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August 7, 2026Journal of Clinical Laboratory AnalysisOpen Access

The Landscape of Biomarkers in ICU ‐Associated AKI : From Protein Markers to Cell‐Free Nucleic Acids

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Authors

ZQZhu QiCentral Hospital Affiliated to Shenyang Medical CollegeFYFeng YangCentral Hospital Affiliated to Shenyang Medical CollegeHZHua ZhengCentral Hospital Affiliated to Shenyang Medical College

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Implication

Randomized trial summarizes biomarker landscape for ICU-associated AKI, indicating diagnostic and prognostic implications.

Key Points

  • To summarize the range of biomarkers for acute kidney injury (AKI) in intensive care units (ICUs).
  • Systematic search of PubMed/MEDLINE and Embase from inception to December 31, 2025.
  • Prioritized studies on ICU patients reporting diagnostic performance and relevant outcomes related to AKI.
  • Focused on kidney-targeted proteins and circulating cell-free DNA, especially in conditions like sepsis and trauma.
  • NGAL, KIM-1, IL-18, L-FABP, and [TIMP-2]·[IGFBP7] levels often increase before changes in creatinine or urine output, indicating early kidney injury.
  • cfDNA and mtDNA indicate systemic cell death and organ damage, enhancing prognostic information beyond traditional metrics.
  • Combining clinical risk factors with early biomarkers may better identify patients at risk for severe AKI and related complications.

Cite This Study

Qi et al. (2026) studied this question.

synapsesocial.com/papers/6a758bae847ab6d26c01f20fhttps://doi.org/10.1002/jcla.70311
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Also Consider

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  1. 1Cell-free DNA predicts all-cause mortality of sepsis-induced acute kidney injury2024 · 13 citations
  2. 2Urinary Biomarkers in the Early Detection of Acute Kidney Injury after Cardiac Surgery2009 · 428 citations
  3. 3AKI and Long-Term Risk for Cardiovascular Events and Mortality2016 · 396 citations
  4. 4Soluble Urokinase Receptor and Acute Kidney Injury2020 · 215 citations
  5. 5Oliguria in critically ill patients: a narrative review2018 · 67 citations