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This study synthesizes systematic reviews on interventions for managing fatigue in multiple sclerosis (MS).

Measurements and management of multiple sclerosis-related fatigue: an umbrella review and meta-analysis

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Umbrella review synthesizes interventions for MS-related fatigue, highlighting exercise and therapy benefits.

This study synthesizes systematic reviews on interventions for managing fatigue in multiple sclerosis (MS).
Reviewed 46 systematic reviews with meta-analyses assessing various interventions for MS-related fatigue.
Effects were measured using standardized mean differences (SMDs) with 95% confidence intervals.
Methodological quality of reviews was assessed using AMSTAR-2.
Aerobic training significantly reduced fatigue with SMD -0.32, while resistance exercise and yoga showed larger heterogeneous effects (-1.09 and -0.70, respectively).
Cognitive behavioral therapy and mindfulness therapies provided small to moderate improvements in fatigue management.
Transcranial direct current stimulation had a significant short-term effect (-1.02) on reducing fatigue.

Hawas et al. (2026) studied this question.

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