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August 7, 2026NutrientsOpen Access

The Effects of Neurotropic B Vitamins, Vitamin D3, and Alpha-Lipoic Acid in In Vitro Models of Neurodegeneration

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Authors

CVChristian VielMétéo-FranceYSYing ShiShanghai UniversityRTRyan P. TruemanUniversity College London

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Implication

In vitro models reveal neuro-regenerative potentials of B vitamins and vitamin D3 in peripheral neuropathy, indicating treatment avenues.

Key Points

  • This research aims to assess the regenerative effects of neurotropic B vitamins, vitamin D3, and alpha-lipoic acid on neurite degeneration in vitro.
  • In vitro models induced degeneration using hydrogen peroxide and homocysteine.
  • Evaluated the effects of vitamins B1, B6, B12, and D3, along with alpha-lipoic acid on neurite outgrowth.
  • Combination of vitamins B1, B6, and B12 significantly improved neurite extension after homocysteine degeneration.
  • All three neurotropic B vitamins showed superior regenerative effects compared to individual treatments.
  • Vitamin D3 positively impacted neurite growth in both healthy and damaged neural cells.

Cite This Study

Viel et al. (2026) studied this question.

synapsesocial.com/papers/6a758bd0847ab6d26c01f5d6https://doi.org/10.3390/nu18152555
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of ALA on preventing diabetic peripheral neuropathy in rats through mitochondrial axonal transport2026 · 1 citations
  2. 2Advances in the pathophysiology and treatment of diabetic peripheral neuropathy2026 · 9 citations
  3. 3Diabetic Peripheral Neuropathy: New Diagnostics and Treatment Perspectives2025
  4. 4Oxidative Stress and Mitochondrial Dysfunction Associated with Peripheral Neuropathy in Type 1 Diabetes2021 · 82 citations
  5. 5Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes2015 · 238 citations