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November 12, 2025International Journal of Molecular SciencesOpen Access

Synergistic Effect Evaluation and Mechanism Investigation of Vitamin B6 and B12 in Models of Neuroinflammation

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Authors

DXDou XixiSCShiru CaiYLYingbo Liu

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Overview

Synergistic effect of vitamin B12 and proteolipid protein 1 improves neuroinflammation in mouse models, indicating novel therapeutic potential.

Key Points

  • Combination therapy with vitamin B12 and proteolipid protein 1 significantly reduced neuroinflammation in mouse models.
  • Treatment regimen showed improved outcomes associated with key neuroprotective markers and reduced oxidative stress.
  • Molecular docking revealed high-affinity interactions for vitamin B12, enhancing its neuroprotective role when combined with other agents.
  • Findings highlight the potential of targeted nanocarriers to cross the blood-brain barrier effectively.

Cite This Study

Xixi et al. (2025) studied this question.

synapsesocial.com/papers/692523d4c0ce034ddc3555d7https://doi.org/10.3390/ijms262210956
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Also Consider

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  1. 1The Effects of Neurotropic B Vitamins, Vitamin D3, and Alpha-Lipoic Acid in In Vitro Models of Neurodegeneration2026
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  3. 3Synergistic efficacy of combined neurolysis and methylcobalamin in peripheral nerve injury: a randomized clinical trial2026
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  5. 5Vitamin B6 Prevents IL-1β Protein Production by Inhibiting NLRP3 Inflammasome Activation2016