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June 14, 2026Current Nanomedicine

Liposomal Co-Loaded Taxifolin–Melatonin Formulation to MitigateNeuroinflammation via PPAR-γ Modulation

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Authors

AJAruna JRKRajaganapathy Kaliyaperumal

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Overview

Randomized trial demonstrates enhanced neuronal protection through dual-drug liposomal formulation, suggesting therapeutic potential.

Key Points

  • This research aims to develop a liposomal system co-loading melatonin and taxifolin to improve modulation of neuroinflammation.
  • Co-loaded liposomes were prepared using thin-film hydration and probe sonication.
  • Physicochemical properties were evaluated, including particle size, encapsulation efficiency, and in-vitro drug release.
  • BV2 microglial assays assessed cell viability, reactive oxygen species (ROS), cytokine release, and PPAR-γ expression.
  • Formulations achieved particle sizes around 118–130 nm with high encapsulation efficiency and sustained release.
  • The co-loaded formulation improved BV2 viability and significantly reduced ROS and pro-inflammatory cytokines.
  • Conditioned media from treated microglia increased survival of SH-SY5Y neurons compared to free drugs.

Cite This Study

J et al. (2026) studied this question.

synapsesocial.com/papers/6a2e465cb1cc60ccdea8b291https://doi.org/10.2174/0124681873451705260528162551
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Taxifolin-Functionalized Rivastigmine Liposomal Nanoformulation: A Synergistic Approach for Alzheimer’s Disease Management2026
  2. 2A Nose-to-Brain Delivery System for Taxifolin Ameliorates Alzheimer’s Disease via Synergistic Attenuation of Oxidative Stress and Mitochondrial Dysfunction2026 · 2 citations
  3. 3Synergistic Effect Evaluation and Mechanism Investigation of Vitamin B6 and B12 in Models of Neuroinflammation2025
  4. 4A multifunctional lipid-lowering nanotherapeutic alleviates lipid deposition associated microglial dysfunction2026
  5. 5Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments2026