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June 20, 2026Pharmaceutical Nanotechnology

Taxifolin-Functionalized Rivastigmine Liposomal Nanoformulation: A Synergistic Approach for Alzheimer’s Disease Management

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Authors

MFM x FC ller F.-M.RKRajaganapathy Kaliyaperumal

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Overview

Randomized trial evaluates a novel liposomal formulation for Alzheimer’s treatment, highlighting significant neuroprotection.

Key Points

  • The study aims to develop a Taxifolin-decorated Rivastigmine liposomal nanocarrier to enhance neuroprotection in Alzheimer's disease.
  • Taxifolin was covalently conjugated to DSPE-PEG and incorporated into drug-loaded liposomes.
  • Characterization involved DLS, TEM, FTIR, and DSC techniques.
  • In vitro and in vivo assessments were performed using an ICV-STZ-induced Alzheimer’s rat model.
  • Tax-Riva-Lipo showed uniform nanosized vesicles (~145 nm) and high encapsulation efficiency (≈85%).
  • Significantly enhanced AChE and BuChE inhibition with IC₅₀ values of 0.08 μM and 0.52 μM respectively.
  • In vivo results included improved cognitive performance and restoration of antioxidant enzymes without detectable toxicity.

Cite This Study

F.-M. et al. (2026) studied this question.

synapsesocial.com/papers/6a3631a1db0793dc1a538688https://doi.org/10.2174/0122117385456970260609153349
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Also Consider

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  3. 3A Nose-to-Brain Delivery System for Taxifolin Ameliorates Alzheimer’s Disease via Synergistic Attenuation of Oxidative Stress and Mitochondrial Dysfunction2026 · 2 citations
  4. 4Liposomal Co-Loaded Taxifolin–Melatonin Formulation to MitigateNeuroinflammation via PPAR-γ Modulation2026
  5. 5Investigation of liposome formulation effects on rivastigmine transport through human colonic adenocarcinoma cell line (CACO-2)2010