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April 30, 2026˜Die œPharmazieOpen Access

Investigation of liposome formulation effects on rivastigmine transport through human colonic adenocarcinoma cell line (CACO-2)

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Authors

ZDZ. DeğimNMN. B. MutluŞYŞ. Yılmaz

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Overview

Investigations show rivastigmine transport efficacy in Caco-2 cells, suggesting liposome formulation enhances permeability.

Key Points

  • To investigate the effects of liposome formulation on the transport of rivastigmine through Caco-2 cells.
  • Conducted in vitro studies using MTT test for cell viability.
  • Prepared and characterized various liposome formulations containing rivastigmine.
  • Determined encapsulation efficiencies and stability metrics of liposomes.
  • Assessed penetration properties and permeability coefficients through Caco-2 cells and diffusion studies.
  • Evaluated AChE activity and inhibition in animal models using Ellman method.
  • Highest % cumulative rivastigmine transport was 87.2% for rivastigmine-sodium taurocholate solution.
  • Permeability coefficient value of -0.75 was achieved with sodium taurocholate liposomes.
  • AChE inhibition was highest in rivastigmine and sodium taurocholate liposomes.

Cite This Study

Değim et al. (2010) studied this question.

synapsesocial.com/papers/69f2a4f18c0f03fd67764084https://doi.org/10.31083/ph.2010.9179
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