Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 20, 2025Open Access

Formulation of Rivastigmine-Loaded Nanolipid Mucoadhesive Gel Using Moringa oleifera Mucilage for Enhanced Mucosal Delivery in Alzheimer’s Disease

View Full Paper
Ask AI
Bookmark
Share

Authors

BDBhaswati DasSRM Institute of Science and TechnologyMUMarakanam Srinivasan UmashankarSRM Institute of Science and Technology

Discussion

Loading...

Member takes

Implication

Research demonstrates enhanced bioavailability of rivastigmine in Alzheimer's via a novel mucilage gel, indicating improved patient compliance.

Key Points

  • The study aims to formulate a rivastigmine-loaded gel to enhance mucosal drug delivery in Alzheimer's disease.
  • Developed a nanolipid mucoadhesive gel using Moringa oleifera mucilage.
  • Evaluated dual mucosal application (nasal and buccal) for improved drug delivery.
  • Assessed drug encapsulation stability and release profile.
  • Moringa oleifera mucilage enhanced mucoadhesion and biocompatibility.
  • The gel formulation improved bioavailability compared to oral rivastigmine.
  • Controlled release provided sustained therapeutic effects for Alzheimer's management.

Cite This Study

Das et al. (2025) studied this question.

synapsesocial.com/papers/6945e9325151ab1219e4d640https://doi.org/10.20944/preprints202512.1582.v1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Formulation and characterization of polymeric nanoparticle of Rivastigmine for effective management of Alzheimer’s disease2024 · 26 citations
  2. 2Design and Optimization of a Mucoadhesive Gel Containing Solid Lipid Nanoparticles for Sublingual and Nasal Delivery of a Low Bioavailable Drug2025 · 1 citations
  3. 3Formulation and Evaluation of Nasal Microspheres2025
  4. 4Synthesis of a Rivastigmine and Insulin Combinational Mucoadhesive Nanoparticle for Intranasal Delivery2024 · 26 citations
  5. 5TO DESIGN, DEVELOP, AND OPTIMIZE A GALANGIN LOADED THERMOSENSITIVE IN-SITU NASAL GEL FOR ALZHEIMER'S DISEASE2026