Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 13, 2026Open Access

To Design, Develop, and Optimize a Galangin Loaded Thermosensitive in-Situ Nasal Gel for Alzheimer's Disease

View Full Paper
Ask AI
Bookmark
Share

Authors

D3Dr. Shinde R.*1, Bade Kanchan K. 2, Dr. Bargaje Goraksh S. 3

Discussion

Loading...

Member takes

Implication

Randomized trial develops a galangin nasal gel for drug delivery in Alzheimer’s patients, suggesting improved treatment options.

Key Points

  • The aim is to create and enhance a galangin-loaded nasal gel for better drug delivery in Alzheimer’s disease.
  • Developed a nasal in-situ gel using Poloxamer 407 and Moringa gum.
  • Used a 3² factorial design to optimize the formulation based on gelling temperature and mucoadhesive strength.
  • Evaluated physicochemical properties and conducted ex vivo permeation tests through goat nasal mucosa.
  • The optimized formulation (F5) achieved a gelling temperature of 32.9 °C and mucoadhesive strength of 4562 dynes/cm².
  • Ex vivo tests showed 78.46% cumulative permeation over 12 hours.
  • Stability tests demonstrated robustness under accelerated conditions.

Cite This Study

Dr. Shinde R.*1, Bade Kanchan K. 2, Dr. Bargaje Goraksh S. 3 (2026) studied this question.

synapsesocial.com/papers/6a7d76d82b0e0cff3f64080dhttps://doi.org/10.5281/zenodo.21886122
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Feasibility Study of Nose-to-Brain Delivery of Galantamine for Alzheimer’s Disease: Enhancing Olfactory-Region Deposition to Improve Therapeutic Efficacy2026
  2. 2Formulation of Rivastigmine-Loaded Nanolipid Mucoadhesive Gel Using <em>Moringa oleifera</em> Mucilage for Enhanced Mucosal Delivery in Alzheimer’s Disease2025
  3. 3Quality-By-Design (QBD) Approach in Developing a Thermoresponsive In-Situ Nasal Gel Containing Nanosized Antiviral2025
  4. 4Breaking Barriers: Intranasal Microemulsions for the Efficient Nose-to-brain Delivery of Glycyrrhetinic Acid2026 · 1 citations
  5. 5Orodispersible Hydrogel Film Technology for Optimized Galantamine Delivery in the Treatment of Alzheimer’s Disease2025