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August 19, 2025Open Access

Design and Optimization of a Mucoadhesive Gel Containing Solid Lipid Nanoparticles for Sublingual and Nasal Delivery of a Low Bioavailable Drug

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Authors

BDBhaswati DasSRM Institute of Science and TechnologyUSUmashankar Marakanam SrinivasanSRM Institute of Science and Technology

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Implication

Development of mucoadhesive gel using Moringa oleifera improves drug bioavailability via nasal and sublingual routes.

Key Points

  • The mucoadhesive gel significantly enhances drug absorption, providing a sustained release over six hours.
  • In vitro release tests demonstrate the efficacy of solid lipid nanoparticles in delivering poorly absorbed drugs.
  • Formulation involved the use of a novel mucoadhesive polymer derived from Moringa oleifera for improved adhesion.
  • Sublingual and nasal permeation studies show promising results using porcine goat and sheep mucosa models.

Cite This Study

Das et al. (2025) studied this question.

synapsesocial.com/papers/68af56f4ad7bf08b1eadcd9ahttps://doi.org/10.20944/preprints202508.1314.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Formulation of Rivastigmine-Loaded Nanolipid Mucoadhesive Gel Using Moringa oleifera Mucilage for Enhanced Mucosal Delivery in Alzheimer’s Disease2025
  2. 2FORMULATION AND EVALUATION OF MORINGA OLEIFERA SEED OIL NANOGEL2026
  3. 3Enhancing Mucus Penetration and Intestinal Epithelial Transport of Diacylglycerol Nanoparticles by Surface-Modification2026 · 4 citations
  4. 4Mucoadhesive Moringa Oleifera gel: nutraceutical with higher residence time for oral ulcer management2026
  5. 5Extraction, development, and ex-vivo evaluation of thermoresponsive mucoadhesive in-situ nasal gel incorporating Lablab purpureus mucilage and Pluronic F127 for enhanced intranasal delivery of Diclofenac Sodium2026