What question did this study set out to answer?

To formulate and evaluate a sustained-residence mucoadhesive buccal gel utilizing Moringa oleifera leaf extract and tamarind seed polysaccharide for managing oral ulcers.

August 15, 2026Scientific ReportsOpen Access

Mucoadhesive Moringa Oleifera gel: nutraceutical with higher residence time for oral ulcer management

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Authors

DSDebasish SahooSiksha O Anusandhan University VRVaraprasad R. ReguSiksha O Anusandhan University KTKrishna V TompeSiksha O Anusandhan University

Discussion

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Implication

Preclinical study demonstrates that a mucoadhesive Moringa oleifera gel improves oral ulcer healing in animal models, suggesting a viable plant-based nutraceutical therapy.

Key Points

To formulate and evaluate a sustained-residence mucoadhesive buccal gel utilizing Moringa oleifera leaf extract and tamarind seed polysaccharide for managing oral ulcers.
Quantified active phytocomponents (quercetin, riboflavin, ferulic acid, and chlorogenic acid) in Moringa oleifera leaf extract.
Formulated a mucoadhesive buccal gel with tamarind seed polysaccharide and evaluated compatibility, mechanical properties, and mucoadhesion against a commercial comparator.
Assessed in vivo therapeutic efficacy in animal models of chemically induced oral ulcers and diabetic ulcerations.
The optimized gel formulation demonstrated adequate compatibility and mechanical properties, achieving an extended buccal residence time of 2 hours.
Gel application effectively managed chemically induced oral ulcers and reduced ulcerations in diabetic animal models.

Cite This Study

Sahoo et al. (2026) studied this question.

synapsesocial.com/papers/6a80197375c2e31742c85798 https://doi.org/10.1038/s41598-026-66813-6

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August 15, 2026Scientific ReportsOpen Access

Mucoadhesive Moringa Oleifera gel: nutraceutical with higher residence time for oral ulcer management

View Full Paper

Ask AI

Bookmark

Authors

DSDebasish SahooSiksha O Anusandhan University VRVaraprasad R. ReguSiksha O Anusandhan University KTKrishna V TompeSiksha O Anusandhan University

Discussion

Member takes

Implication

Preclinical study demonstrates that a mucoadhesive Moringa oleifera gel improves oral ulcer healing in animal models, suggesting a viable plant-based nutraceutical therapy.

Key Points

To formulate and evaluate a sustained-residence mucoadhesive buccal gel utilizing Moringa oleifera leaf extract and tamarind seed polysaccharide for managing oral ulcers.
Quantified active phytocomponents (quercetin, riboflavin, ferulic acid, and chlorogenic acid) in Moringa oleifera leaf extract.
Formulated a mucoadhesive buccal gel with tamarind seed polysaccharide and evaluated compatibility, mechanical properties, and mucoadhesion against a commercial comparator.
Assessed in vivo therapeutic efficacy in animal models of chemically induced oral ulcers and diabetic ulcerations.
The optimized gel formulation demonstrated adequate compatibility and mechanical properties, achieving an extended buccal residence time of 2 hours.
Gel application effectively managed chemically induced oral ulcers and reduced ulcerations in diabetic animal models.

Cite This Study

Sahoo et al. (2026) studied this question.

synapsesocial.com/papers/6a80197375c2e31742c85798 https://doi.org/10.1038/s41598-026-66813-6

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