“Extraction, Development, and Ex-Vivo Evaluation of Thermoresponsive Mucoadhesive In-Situ Nasal Gel Incorporating Lablab purpureus Mucilage and Pluronic F127 for Enhanced Intranasal Delivery of Diclofenac Sodium”

OBJECTIVE: mucilage with Pluronic F127 yields a stable, mucoadhesive gel enhancing Diclofenac nasal delivery. METHODS: release, permeation, kinetic modeling, six-month stability, and histopathological safety on goat nasal mucosa were also assessed. FA6 exhibited 95.8% release and 96.8% permeation following First-Order kinetics, while FB6 followed the Korsmeyer-Peppas model. CONCLUSIONS: FA6 demonstrated optimal mucoadhesion, permeation, and stability, confirming strong potential as an effective thermoresponsive nasal delivery system for Diclofenac Sodium.