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This research aims to develop an effective nasal delivery system for taxifolin to treat Alzheimer's disease by improving brain bioavailability.

February 8, 2026AntioxidantsOpen Access

A Nose-to-Brain Delivery System for Taxifolin Ameliorates Alzheimer’s Disease via Synergistic Attenuation of Oxidative Stress and Mitochondrial Dysfunction

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A novel delivery system enhances brain bioavailability of taxifolin, reducing oxidative stress in Alzheimer's disease.

This research aims to develop an effective nasal delivery system for taxifolin to treat Alzheimer's disease by improving brain bioavailability.
Developed taxifolin-loaded thermosensitive hydrogel (TF-Gel) for intranasal administration.
Evaluated structural stability and functional performance of TF-Gel.
Assessed the effects of TF-Gel on mitochondrial function and oxidative stress markers in neuronal cells.
TF-Gel improves brain delivery and tissue penetration via intranasal administration.
It regulates mitochondrial dysfunction and reverses abnormal ATP, ROS, and MDA levels.
TF-Gel effectively enhances mitochondrial energy metabolism and reduces oxidative stress damage.

Zhang et al. (2026) studied this question.

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