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To investigate the role of a nasal taxifolin hydrogel in regulating the TLR4/NF-κB/HIF-1α axis and suppressing ferroptosis in Alzheimer’s disease.

March 5, 2026AntioxidantsOpen Access

A Nasal Taxifolin Hydrogel Targets the TLR4/NF-κB/HIF-1α Axis to Suppress Ferroptosis in Alzheimer’s Disease

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To investigate the role of a nasal taxifolin hydrogel in regulating the TLR4/NF-κB/HIF-1α axis and suppressing ferroptosis in Alzheimer’s disease.
Development of a thermosensitive hydrogel for nasal delivery of taxifolin.
Induction of Alzheimer's-like symptoms in mice using Okada acid.
Assessment of cognitive function, neuroinflammation, and oxidative stress following TF-Gel treatment.
Western blot analysis of ferroptosis and apoptosis-related proteins.
TF-Gel significantly improved cognitive dysfunction in the AD mouse model.
Reduced neuroinflammation and oxidative stress were observed after TF-Gel administration.
Inhibition of the TLR4/NF-κB/HIF-1α pathway led to decreased accumulation of reactive oxygen species.
Co-administration of Erastin negated the protective effects of TF-Gel, confirming the role of ferroptosis inhibition.

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Exploratory research demonstrates improved cognitive function in Alzheimer’s disease, suggesting new therapeutic strategies.

Zhang et al. (2026) studied this question.

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