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June 19, 2026Shengming kexue

Research progress on ferroptosis mediated by ferritinophagy in Alzheimer′s disease

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Authors

AZAi-Ting ZhangZJZhong Jian-minPJPei-Wen Jia

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Overview

Review synthesizes the link between ferroptosis, ferritinophagy, and Alzheimer’s disease pathologies, suggesting new therapies.

Key Points

  • To explore the relationship between ferroptosis and ferritinophagy in Alzheimer's disease and their implications for treatment.
  • Review of molecular mechanisms related to ferroptosis and ferritinophagy in the context of Alzheimer's disease.
  • Analysis of key pathways including NCOA4-dependent ferritin degradation and glutathione axis modulation.
  • Discussion of potential therapeutic targets and unresolved questions for future research.
  • Dysregulated ferritinophagy contributes to iron overload and ferroptosis in Alzheimer's disease.
  • Iron overload enhances Aβ generation and tau hyperphosphorylation, exacerbating neuronal death.
  • Potential therapeutic interventions include natural compounds that modulate the glutathione axis and targets like JWA and TMEM164.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a34de7065a5b0777af2de05https://doi.org/10.3724/cbls.2026059
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ferroptosis in Alzheimer’s Disease: Potential Mechanisms and Intervention Strategies2026
  2. 2The Emerging Role of Ferroptosis-Autophagy-Mitophagy in Alzheimer’s Disease Pathophysiology and Therapy2026
  3. 3Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update2025 · 15 citations
  4. 4The Pathological Nexus and Multipronged Approaches to Mitigate Ferroptosis and Alzheimer’s Disease2025 · 9 citations
  5. 5The interplay between mitophagy and ferroptosis in Alzheimer’s disease: Mechanisms and therapeutic implications2026