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March 15, 2026Journal of Alzheimer s Disease

The interplay between mitophagy and ferroptosis in Alzheimer’s disease: Mechanisms and therapeutic implications

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Authors

ALAnnan LiuLXLiping XingJLJing Li

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Overview

This review demonstrates the feedback loop between mitophagy and ferroptosis in Alzheimer’s disease, suggesting therapeutic strategies may mitigate neurodegeneration.

Key Points

  • This work aims to explore the interplay between mitophagy and ferroptosis in the progression of Alzheimer’s disease.
  • Reviewing literature on mitophagy and ferroptosis mechanisms in Alzheimer’s disease.
  • Highlighting therapeutic strategies targeting this interplay.
  • Synthetizing evidence of self-amplifying feedback loops between impaired mitophagy and ferroptosis.
  • Identified mitophagy disruption increases neuronal susceptibility to ferroptosis.
  • Established a vicious cycle between mitochondrial dysfunction and lipid peroxidation.
  • Proposed potential therapeutic approaches like Urolithin A and ferroptosis inhibitors.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff4f83145bc643d1ba87https://doi.org/10.1177/13872877261420211
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Emerging Role of Ferroptosis-Autophagy-Mitophagy in Alzheimer’s Disease Pathophysiology and Therapy2026
  2. 2Ferroptosis in Alzheimer’s Disease: Potential Mechanisms and Intervention Strategies2026
  3. 3Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update2025 · 15 citations
  4. 4Research progress on ferroptosis mediated by ferritinophagy in Alzheimer′s disease2026
  5. 5The Pathological Nexus and Multipronged Approaches to Mitigate Ferroptosis and Alzheimer’s Disease2025 · 9 citations