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September 27, 2025Journal of Medicinal Chemistry

The Pathological Nexus and Multipronged Approaches to Mitigate Ferroptosis and Alzheimer’s Disease

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Authors

HMHariharan MoorthySSS. SainDPDikshaa Padhi

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Overview

This perspective explores ferroptosis and neurodegeneration in Alzheimer's disease, suggesting new therapeutic avenues.

Key Points

  • Ferroptosis plays a significant role in neuronal loss associated with Alzheimer's disease, highlighting a crucial therapeutic target.
  • Evidence shows that key biomarkers of ferroptosis align with hallmark features of Alzheimer's disease, affecting disease progression.
  • Current therapies like lipid peroxidation inhibitors show promise but need to focus on regulating ferroptosis for enhanced efficacy.
  • Targeting ferroptosis regulators like GPX4 and FSP1 could lead to innovative strategies in treating Alzheimer's disease.

Cite This Study

Moorthy et al. (2025) studied this question.

synapsesocial.com/papers/68d7cc6aeebfec0fc5238b2dhttps://doi.org/10.1021/acs.jmedchem.5c00917
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ferroptosis in Alzheimer’s Disease: Potential Mechanisms and Intervention Strategies2026
  2. 2The Emerging Role of Ferroptosis-Autophagy-Mitophagy in Alzheimer’s Disease Pathophysiology and Therapy2026
  3. 3Research progress on ferroptosis mediated by ferritinophagy in Alzheimer′s disease2026
  4. 4The interplay between mitophagy and ferroptosis in Alzheimer’s disease: Mechanisms and therapeutic implications2026
  5. 5Ferroptosis in Neuropsychiatric and Neurodegenerative Disorders: Shared Mechanisms and Disease-Specific Signatures2026 · 2 citations