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April 16, 2026International Journal of General MedicineOpen Access

Metabolic Regulatory Networks in Ferroptosis During Alzheimer’s Disease, Mechanisms of Glial Cell Action, and Pathological Correlations with Neuritic Plaques

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Authors

BZBowen ZhangMZMiao Zhang

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Overview

This review explores ferroptosis mechanisms in Alzheimer's disease and its impact on glial cells and neuritic plaques, suggesting intervention strategies.

Key Points

  • The aim is to investigate the relationship between ferroptosis and Alzheimer's disease, focusing on glial cell functions and associated pathological mechanisms.
  • Theoretical analysis of ferroptosis in Alzheimer’s disease pathology.
  • Examination of multiple metabolic pathways influenced by iron, lipids, and amino acids.
  • Analysis of the role of microglia, astrocytes, and oligodendrocytes in ferroptosis.
  • Exploration of the interactions between neuritic plaques and ferroptosis.
  • Ferroptosis is linked to the development of Alzheimer’s disease.
  • Glial cells play a crucial role in the regulation of ferroptosis.
  • Neuritic plaques correlate with ferroptosis and inflammatory responses.
  • Abnormal tau phosphorylation is related to neuronal death via ferroptosis.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69e07cfa2f7e8953b7cbe0fahttps://doi.org/10.2147/ijgm.s596584
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ferroptosis in Alzheimer’s Disease: Potential Mechanisms and Intervention Strategies2026
  2. 2Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update2025 · 15 citations
  3. 3Research progress on ferroptosis mediated by ferritinophagy in Alzheimer′s disease2026
  4. 4The interplay between mitophagy and ferroptosis in Alzheimer’s disease: Mechanisms and therapeutic implications2026
  5. 5Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases2024 · 6 citations