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July 21, 2025Frontiers in Aging NeuroscienceOpen Access

Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update

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Authors

BZBingyuan ZhouJLJing LiAWAnqi Wu

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Overview

This review uncovers the role of ferroptosis in Alzheimer’s disease, highlighting its connection to oxidative damage and iron overload.

Key Points

  • MAIN FINDING: Ferroptosis, a novel cell death form, may contribute to the progression of Alzheimer's disease.
  • KEY EVIDENCE: Pathological features in Alzheimer’s include iron deposition and oxidative stress indicating ferroptosis involvement.
  • APPROACH: The review synthesizes research linking iron overload and redox imbalance to Alzheimer's mechanisms.
  • SIGNIFICANCE: Understanding ferroptosis in Alzheimer's may guide new treatment strategies and drug development.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd1fchttps://doi.org/10.3389/fnagi.2025.1587986
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ferroptosis in Alzheimer’s Disease: Potential Mechanisms and Intervention Strategies2026
  2. 2Metabolic Regulatory Networks in Ferroptosis During Alzheimer’s Disease, Mechanisms of Glial Cell Action, and Pathological Correlations with Neuritic Plaques2026
  3. 3The Emerging Role of Ferroptosis-Autophagy-Mitophagy in Alzheimer’s Disease Pathophysiology and Therapy2026
  4. 4Research progress on ferroptosis mediated by ferritinophagy in Alzheimer′s disease2026
  5. 5The interplay between mitophagy and ferroptosis in Alzheimer’s disease: Mechanisms and therapeutic implications2026