Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 26, 2026Journal of Functional FoodsOpen Access

Combined neuroprotective effects of vitamins B2 and B3 on LPS-induced neuroinflammation: a multi-omics insight into the gut-brain axis

View Full Paper
Ask AI
Bookmark
Share

Authors

ZSZHU ShaohuiNanchang UniversityYCYaru ChenTianjin UniversityYWYì WángBGI Group (China)

Discussion

Loading...

Member takes

Overview

Randomized trial investigates neuroprotection in mice exposed to LPS-induced neuroinflammation, suggesting dietary benefits.

Key Points

  • This study aims to evaluate the neuroprotective effects of vitamins B2 and B3 against neuroinflammation induced by lipopolysaccharides (LPS).
  • Utilized an LPS-induced neuroinflammatory mouse model
  • Conducted behavioral assessments, histopathology, 16S rRNA sequencing, and untargeted metabolomics
  • Analyzed the Sirt1/NF-κB pathway and microbiota changes following B2/B3 supplementation.
  • Combined B2/B3 treatment significantly reduced anxiety-like behaviors and improved spatial memory
  • Intervention lowered hippocampal neuroinflammation and oxidative stress, associated with pathway modulation
  • Restored gut microbiota balance by increasing Akkermansia and decreasing Desulfovibrio, impacting metabolic homeostasis.

Cite This Study

Shaohui et al. (2026) studied this question.

synapsesocial.com/papers/6a65a84ed3aea3239cd78af8https://doi.org/10.1016/j.jff.2026.107436
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Probiotic Bacillus subtilis, but Not a Lactobacillus spp., Ameliorates Cognitive Impairment in a Mouse Model of LPS and Zidovudine-Induced Neuroinflammation2026 · 1 citations
  2. 2Synergistic Effect Evaluation and Mechanism Investigation of Vitamin B6 and B12 in Models of Neuroinflammation2025
  3. 3A novel Mediterranean diet-inspired supplement ameliorates cognitive, microbial, and metabolic deficits in a mouse model of low-grade inflammation2024 · 21 citations
  4. 4Neurocognitive effects of postbiotics from Lactobacillus and Bifidobacterium strains in a mouse model of chronic variable stress2026 · 1 citations
  5. 5Targeting the Gut–Brain Axis: Protective Effects of NMN in Alleviating D-Galactose-Induced Cognitive Deficits2026 · 1 citations