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August 7, 2026Spectroscopy Letters

AI-augmented surface Plasmon Resonance (SPR) fiber sensor simulation in COMSOL v6.2 for ultra-sensitive biosensing applications

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Authors

NONisaan S OraibiSASuha Mousa Khorsheed AlawsiMKMohammed K. Khalaf

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Overview

Randomized trial demonstrates enhanced biosensing accuracy with AI-augmented SPR fiber sensors, suggesting broader applications.

Key Points

  • This study aims to enhance the sensitivity and accuracy of SPR fiber sensors through AI integration and simulation.
  • Conducted simulations in COMSOL Multiphysics to evaluate electromagnetic responses at various wavelengths and angles of incidence.
  • Implemented machine learning techniques, including neural regression and support vector machines, for data analysis and peak detection.
  • Investigated the effects of refractive index variations on resonance excitation under TM polarization.
  • Achieved a sensitivity of approximately 1000 nm/RIU for the proposed biosensor design, outperforming conventional sensors (500-800 nm/RIU).
  • Demonstrated that neural regression improved peak detection in noisy SPR spectra, enhancing analytical precision.
  • Validated the design's feasibility for label-free detection of biological samples, indicating potential in healthcare diagnostics and environmental monitoring.

Cite This Study

Oraibi et al. (2026) studied this question.

synapsesocial.com/papers/6a758bef847ab6d26c01f9e2https://doi.org/10.1080/00387010.2026.2712581
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