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August 7, 2026Journal of Biological EngineeringOpen Access

Dual pH/temperature-responsive β-cyclodextrin-grafted cellulose nanocrystals for co-delivery of methotrexate and curcumin to MCF-7 cells

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Authors

SMSevil Vaghefi MoghaddamTabriz University of Medical SciencesFAFatemeh AbediYasouj UniversitySDSoodabeh DavaranYeditepe University

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Implication

Randomized trial demonstrates effective drug delivery in MCF-7 cells, indicating promise for breast cancer treatment.

Key Points

  • The aim is to create a dual-responsive nanocarrier system for co-delivering methotrexate and curcumin to enhance cancer treatment.
  • Synthesis of β-CD-g-BCN nanocarrier system functionalized with MSP and copolymerized with NIPAAm and DMAEMA.
  • Characterization through FTIR, FESEM, TEM, DLS, zeta potential, and TGA to validate stability and encapsulation efficiencies.
  • In vitro release studies under acidic and hyperthermic conditions to assess drug release profile.
  • Encapsulation efficiencies were 64.5% for methotrexate and 87% for curcumin.
  • Drug release was significantly enhanced at pH 5.8 and 40°C, conditions mimicking the tumor environment.
  • The MTX/CUR-loaded system demonstrated strong synergistic effects on MCF-7 cells with a CI < 0.1.

Cite This Study

Moghaddam et al. (2026) studied this question.

synapsesocial.com/papers/6a758c01847ab6d26c01fb0dhttps://doi.org/10.1186/s13036-026-00738-6
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  5. 5In vitro biological evaluation of a water-soluble hyperbranched β-cyclodextrin nanocarrier for co-delivery of doxorubicin and curcumin2026