What question did this study set out to answer?

To review the clinicopathologic spectrum of benign, premalignant, and malignant endocervical glandular lesions exhibiting gastric differentiation that arise independently of human papillomavirus.

June 8, 2013Advances in Anatomic Pathology

Endocervical Glandular Lesions Exhibiting Gastric Differentiation

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To review the clinicopathologic spectrum of benign, premalignant, and malignant endocervical glandular lesions exhibiting gastric differentiation that arise independently of human papillomavirus.
Synthesized clinicopathologic, morphologic, and immunophenotypic evidence on gastric-differentiated endocervical lesions, including lobular endocervical glandular hyperplasia (LEGH) and minimal deviation adenocarcinoma (MDA).
Evaluated the diagnostic utility of gastric mucin immunophenotypic markers (HIK1083 and MUC6) and described clinical associations such as Peutz-Jeghers syndrome.
Evidence supports a LEGH-to-gastric-type adenocarcinoma (GAS) progression sequence, wherein atypical LEGH serves as a precursor to invasive HPV-negative adenocarcinoma.
Gastric-type adenocarcinomas, including MDA as a well-differentiated variant, exhibit aggressive clinical behavior and are not preventable by HPV vaccination or detectable by HPV-targeted screening.
Lesions consistently display gastric immunophenotypes with HIK1083 and/or MUC6 positivity, necessitating the development of novel screening biomarkers.

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Implication

Pathologic review characterizes HPV-unrelated gastric-type endocervical lesions spanning benign hyperplasia to aggressive adenocarcinoma, highlighting diagnostic challenges for standard screening.

Cite This Study

Mikami et al. (2013) studied this question.

synapsesocial.com/papers/6a758c04dcfefe9676dd7cf0 https://doi.org/10.1097/pap.0b013e31829c2d66

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Implication

Pathologic review characterizes HPV-unrelated gastric-type endocervical lesions spanning benign hyperplasia to aggressive adenocarcinoma, highlighting diagnostic challenges for standard screening.

Endocervical Glandular Lesions Exhibiting Gastric Differentiation

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Discussion

Implication

Cite This Study

Endocervical Glandular Lesions Exhibiting Gastric Differentiation

Key Points

Discussion

Implication

Cite This Study

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