What question did this study set out to answer?

To review the capacity of antihypertensive therapies to reverse cardiac remodeling, normalize myocardial architecture, and restore impaired coronary flow reserve.

January 1, 1994Journal of Cardiovascular Pharmacology

Therapy of Hypertensive Cardiac Hypertrophy and Impaired Coronary Microcirculation

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Why the study?

Does antihypertensive treatment improve coronary flow reserve and reverse cardiac remodeling in hypertension?

Population

Hypertensive patients with microvascular disease and experimental models (spontaneously hypertensive rats)

Design

Review

Authors

WMW. MotzGoethe University Frankfurt BSB. E. StrauerLudwig-Maximilians-Universität München

Discussion

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Implication

May reverse hypertensive remodeling beyond BP reduction; leaves open prospective outcome trials before practice change.

Key Points

To review the capacity of antihypertensive therapies to reverse cardiac remodeling, normalize myocardial architecture, and restore impaired coronary flow reserve.
Synthesized experimental findings in spontaneously hypertensive rats treated with hydralazine, felodipine, lisinopril, nifedipine, or moxonidine.
Evaluated initial clinical evidence regarding coronary flow reserve alterations following prolonged antihypertensive treatment in patients with microvascular disease.
In spontaneously hypertensive rats, hydralazine improved coronary flow reserve without regressing left ventricular hypertrophy, whereas felodipine reversed medial hypertrophy in coronary resistance vessels.
Lisinopril administration enhanced coronary flow reserve and reversed both medial hypertrophy and myocardial fibrosis, while nifedipine and moxonidine increased capillary length density.
Preliminary clinical data demonstrated that sustained antihypertensive therapy improves coronary flow reserve in hypertensive patients exhibiting coronary microvascular disease.

Structured PICO

Does antihypertensive treatment improve coronary flow reserve and reverse cardiac remodeling in hypertension?

Population

Hypertensive patients with microvascular disease and experimental models (spontaneously hypertensive rats)

Intervention

Antihypertensive treatment (including hydralazine, felodipine, lisinopril, nifedipine, moxonidine)

Outcome

Regression of left ventricular hypertrophy and improvement in coronary flow reservesurrogate

Antihypertensive therapy shows potential to not only lower blood pressure but also repair hypertensive cardiac remodeling and improve coronary microcirculation.

Cite This Study

Motz et al. (1994) studied this question.

synapsesocial.com/papers/6a758c3a1cd7cac2185ffc48 https://doi.org/10.1097/00005344-199424001-00007

Topics

Hypertension management

View Full Paper

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Therapy of Hypertensive Cardiac Hypertrophy and Impaired Coronary Microcirculation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Therapy of Hypertensive Cardiac Hypertrophy and Impaired Coronary Microcirculation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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