Beyond Brain Networks: An Integrated Brain–Body–Environment Systems Framework for Resilience, Neuroplasticity, and Adaptive Regulation

For the Zenodo Description field, you want something professional, searchable, and clear. Here's a polished version: This preprint presents the Integrated Adaptive Resilience Systems Model (IARSM), a conceptual systems neuroscience framework proposing that resilience emerges from dynamic interactions among large-scale brain networks, peripheral physiological systems, neuroplasticity, and environmental processes rather than from isolated neural or psychological mechanisms. The manuscript synthesizes evidence from network neuroscience, developmental neuroscience, psychoneuroimmunology, allostasis, predictive processing, complexity science, and precision psychiatry to introduce a unified brain–body–environment model of adaptive regulation. The framework integrates reciprocal interactions among functional brain networks, autonomic regulation, endocrine and immune systems, interoception, the gut–brain axis, sleep, neuroplasticity, and environmental influences to explain adaptive functioning across health and psychopathology. This work is intended as a theoretical contribution to neuroscience and behavioral health, providing an interdisciplinary foundation for future empirical research, computational modeling, biomarker development, and precision mental health interventions.