Why the study?
Does high dose methotrexate lead to the excretion of 7-hydroxymethotrexate in human subjects and rhesus monkeys compared to conventional doses?
Population
Human subjects and rhesus monkeys receiving the antitumor agent methotrexate
Comparison
High dose methotrexate (greater than 50 mg/kg) vs Conventional dose levels of methotrexate
Design
Other
Authors
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Alerts clinicians to metabolite formation in high-dose methotrexate; leaves open its clinical relevance and needs prospective validation.
Does high dose methotrexate lead to the excretion of 7-hydroxymethotrexate in human subjects and rhesus monkeys compared to conventional doses?
High-dose methotrexate therapy leads to dose-dependent in vivo conversion to 7-hydroxymethotrexate in primates.
Jacobs et al. (1976) studied this question.
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