Why the study?
Does elevation of systolic aortic blood pressure affect myocardial function in dogs with left ventricular ischaemia?
Does elevation of systolic aortic blood pressure affect myocardial function in dogs with left ventricular ischaemia?
Raising aortic blood pressure improves myocardial function in small ischaemic lesions but worsens it in extensive ischaemia in a canine model.
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BP elevation may aid limited but harm extensive ischaemia in canine models; leaves open clinical translation and optimal targets.
End-diastolic dilation and reduced systolic shortening are the characteristic dimensional changes during myocardial ischaemia. Elevation of systolic aortic blood pressure by 5.3 kPa (40 mm Hg) normalized shortening and reduced myocardial dilatation when the tissue rendered ischaemic by coronary artery occlusion was less than 20% of the left ventricle. However, when the ischaemic lesion was more extensive, an adverse effect of raising aortic blood pressure was observed.
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LEKVEN et al. (1975) studied this question.
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