Why the study?
Does isobutylmethylxanthine compare to theophylline in cardiac and coronary vasodilator effects in isolated dog heart preparations?
Population
Isolated, blood-perfused papillary muscle, sino-atrial node and atrioventricular node preparations of dogs
Comparison
Isobutylmethylxanthine injected intra-arterially vs Theophylline injected intra-arterially
Design
Preclinical
Authors
Loading...
No immediate clinical implications from canine preparations; leaves open translation of IBMX potency to human cardiac effects.
Does isobutylmethylxanthine compare to theophylline in cardiac and coronary vasodilator effects in isolated dog heart preparations?
IBMX and theophylline exhibit nearly identical cardiac and coronary vasodilator profiles in dog heart preparations, with IBMX being 40-50 times more potent, likely via cyclic AMP phosphodiesterase inhibition.
TAKAHASHl et al. (1986) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: