Why the study?
Do selective beta-adrenoceptor blocking drugs (practolol and butoxamine) alter myocardial hemodynamics and the response to isoprenaline in anesthetized cats?
Population
Anaesthetized cats
Comparison
Practolol or Butoxamine followed by isoprenaline… vs Isoprenaline infusions alone
Design
Preclinical
Authors
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Indicates potential for cardioselective beta-blockade to blunt catecholamine effects without compromising flow; leaves open human translation from this animal model.
Do selective beta-adrenoceptor blocking drugs (practolol and butoxamine) alter myocardial hemodynamics and the response to isoprenaline in anesthetized cats?
Practolol abolishes the cardiac stimulant and oxygen-wasting effects of catecholamines without directly reducing myocardial blood flow, indicating potential efficacy as an anti-anginal agent.
Parratt et al. (1970) studied this question.
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