Key result
Oral metoprolol inhibits catecholamine-induced tachycardia and ischemia in angina, matching or outperforming practolol.
Why the study?
The inhibitory effects of metoprolol, a new cardioselective β-blocker, on catecholamine-induced cardiac ischemia compared to propranolol and practolol were not fully characterized.
Does metoprolol inhibit catecholamine-induced cardiac ischemia and acceleration compared to propranolol and practolol in healthy controls and angina patients?
Does metoprolol inhibit catecholamine-induced cardiac ischemia and acceleration compared to propranolol and practolol in healthy controls and angina patients?
Metoprolol is effective in inhibiting catecholamine-induced cardiac ischemia and angina, showing comparable or superior efficacy to practolol.
No takes yet. Share an insight, caveat, or question.
Early hemodynamic data in healthy volunteers; leaves open comparative efficacy and safety in patients with cardiovascular disease.
Miyahara et al. (1978) studied Angina pectoris (n=11). Metoprolol vs. Practolol 100 mg was evaluated on Inhibition of catecholamine-induced cardiac ischemia (heart rate, cardiac effort index, pressure rate index, and ECG ischemic alterations). Oral administration of 40 mg metoprolol significantly inhibited catecholamine-induced tachycardia, ischemic ECG alterations, and anginal episodes in patients with angina pectoris, demonstrating equivalent or superior efficacy to 100 mg practolol.
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