Key result
Propranolol produces ~7-fold stronger blockade of isoproterenol inotropic and chronotropic effects than metoprolol.
Why the study?
Does propranolol produce a more intense blockade of the inotropic and chronotropic effects of isoproterenol than metoprolol in male volunteers?
Population
8 male volunteers
Comparison
Metoprolol 50 mg orally every 6 hours for a… vs Propranolol 40 mg orally every 6 hours for a…
Design
Other
Authors
Loading...
Propranolol's stronger blockade in healthy volunteers should not guide therapy; leaves open differential effects in patients with cardiovascular disease.
Does propranolol produce a more intense blockade of the inotropic and chronotropic effects of isoproterenol than metoprolol in male volunteers?
Absolute Event Rate: 44.4% vs 6.2%
Propranolol produces a much more intense blockade of the inotropic and chronotropic effects of isoproterenol than metoprolol in healthy volunteers.
Kenneth A. Conrad (1981) studied Healthy volunteers (n=8). Propranolol vs. Metoprolol (50 mg orally every 6 hours for five doses) was evaluated on Dose of isoproterenol required to produce an increase in heart rate of 25 beats/min (ID25). Propranolol produced a much more intense blockade of the inotropic and chronotropic effects of isoproterenol than metoprolol (ID25 44.4 vs 6.2 microgram).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: