Key result
IV isoproterenol increases LVEDD by ~2 mm while oral propranolol decreases it in normal subjects.
Why the study?
The effects of nonselective beta-receptor stimulation and blockade on left ventricular size and function were assessed to understand their impact on cardiac output and venous return.
How do nonselective beta-receptor stimulation (isoproterenol) and blockade (propranolol) affect left ventricular size and function in normal subjects?
How do nonselective beta-receptor stimulation (isoproterenol) and blockade (propranolol) affect left ventricular size and function in normal subjects?
Nonselective beta-receptor stimulation and blockade can affect cardiac output through direct cardiac actions and by influencing venous return.
No takes yet. Share an insight, caveat, or question.
Should not change beta-agonist or antagonist use; leaves open effects on LV size in patients with cardiovascular disease.
Leenen et al. (1983) studied Healthy subjects (n=11). Intravenous isoproterenol and oral propranolol vs. Baseline was evaluated on Left ventricular end-diastolic (LVED) dimension. Intravenous isoproterenol increased left ventricular end-diastolic dimension from 46.6 mm to 48.8 mm, whereas oral propranolol decreased it to 45 mm in normal subjects.
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