Key result
The SK-121 digital health intervention did not significantly reduce the SMART2 risk score at 6 months compared to standard of care alone in patients following percutaneous coronary intervention.
Why the study?
To evaluate a multimodal digital health intervention (SK-121) as an adjunct to standard of care to reduce the risk of recurrent cardiovascular events in patients following PCI.
Does a multimodal digital health intervention added to standard of care reduce the SMART2 risk score in patients following percutaneous coronary intervention?
Population
200 patients who underwent PCI
Comparison
SoC plus a 48-week gamified digital program vs SoC alone
Design
Single-centre randomised controlled trial
Follow-up
6 months for primary endpoint, up to 12 months
Authors
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Does not support routine SK-121 use to lower recurrent risk post-PCI; leaves open potential benefit in overweight patients.
RCT (n=200)
Open-label
1:1
No
Does a multimodal digital health intervention added to standard of care reduce the SMART2 risk score in patients following percutaneous coronary intervention?
Mean Difference: -0.3 (95% CI -2.4–1.9)
Absolute Event Rate: 23.9% vs 24.2%
p-value: p=0.821
A 48-week digital health intervention after PCI did not significantly reduce the SMART2 risk score at 6 months compared to standard of care, though it improved disease knowledge and short-term medication adherence.
Guðmundsson et al. (2026) conducted an RCT in Coronary artery disease following percutaneous coronary intervention (n=200). SK-121 digital health program vs. Standard of care alone was evaluated on Baseline-adjusted between-group difference in the SMART2 risk score at 6 months (adjusted mean difference -0.3%, 95% CI -2.4 to 1.9, p=0.821). The SK-121 digital health intervention did not significantly reduce the SMART2 risk score at 6 months compared to standard of care alone in patients following percutaneous coronary intervention.
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