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August 1, 2026Cardiovascular Intervention and Therapeutics

App-based lifestyle modification after percutaneous coronary intervention: A multicenter randomized controlled trial

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Key result

An app-based lifestyle modification program did not significantly increase the proportion of post-PCI patients achieving ≥10% improvement in peak VO2 compared to usual care (41% vs. 39%, p=0.786).

Why the study?

Long-term outcomes after PCI remain suboptimal largely due to non-target lesion progression, and digital health lifestyle interventions may provide an alternative to standard care.

Population

152 post-PCI patients

Comparison

14-week app-based lifestyle modification program using IoT devices vs usual care

Design

Multicenter open-label randomized controlled trial

Follow-up

14-week

Authors

SYSumio YamadaHAHironobu AshikawaKFKuya Funaki

Discussion

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Overview

App-based program failed to improve peak VO2 post-PCI; leaves open whether refined digital tools can enhance risk factor control.

Key Points

  • This research aims to assess the effectiveness of an app-based lifestyle modification program after percutaneous coronary intervention.
  • Multicenter, open-label, randomized controlled trial with 152 post-PCI patients.
  • Participants assigned to a 14-week app-based program or usual care with modified intention-to-treat analysis.
  • Primary endpoint: ≥ 10% improvement in peak oxygen uptake; secondary endpoints included coronary risk factors and quality of life.
  • No significant difference in achieving ≥ 10% improvement in peak VO2 (41% intervention vs. 39% control, p = 0.786).
  • Lipid control was better in the intervention group (56.0% vs. 39.5%, p = 0.042).
  • Indications of superior management of coronary risk factors in the intervention group from complete-case analysis.

Study Design

Type

RCT (n=152)

Blinding

Open-label

Randomization

randomized

Multicenter

Yes

PICO

P
Population
152 post-PCI patients (mean age 60.3 years, 9.9% female) followed for 14 weeks.
I
Intervention / Comparator
App-based lifestyle modification program using IoT devices vs Usual care
O
Primary Outcome
Proportion achieving ≥ 10% improvement in peak oxygen uptake (VO2), p=0.786

Main Result

Absolute Event Rate: 41% vs 39%

p-value: p=0.786

Cite This Study

Yamada et al. (2026) conducted an RCT in post-PCI (n=152). App-based lifestyle modification program using IoT devices vs. Usual care was evaluated on Proportion achieving ≥ 10% improvement in peak oxygen uptake (VO2) (p=0.786). An app-based lifestyle modification program did not significantly increase the proportion of post-PCI patients achieving ≥10% improvement in peak VO2 compared to usual care (41% vs. 39%, p=0.786).

synapsesocial.com/papers/6a6db46de258b358b3c6cb7fhttps://doi.org/10.1007/s12928-026-01328-5
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