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January 7, 2005Proceedings of the National Academy of SciencesOpen Access

Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo

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Population

Congenic endothelial NO synthase-deficient (eNOS-/-) mice and wild-type (WT) mice

Comparison

Intraplantar injection of carrageenan or… vs Wild-type (WT) mice; uninhibited state

Design

Preclinical

Follow-up

Up to 96 hours

Authors

MBMariarosaria BucciFederico II University HospitalFRFiorentina RoviezzoFederico II University HospitalIPInmaculada PosadasUniversity of Castilla-La Mancha

Discussion

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Implication

Hypothesis-generating for eNOS-targeted modulation of vascular leakage; human studies needed before clinical relevance.

Structured PICO

P
Population
Congenic endothelial NO synthase-deficient (eNOS-/-) mice and wild-type (WT) mice
I
Intervention
Intraplantar injection of carrageenan or zymosan; inhibition of phosphatidylinositol 3-kinase or hsp90
C
Comparator
Wild-type (WT) mice; uninhibited state
O
Outcome
Inflammatory response (edema formation, leukocyte infiltration, and protein extravasation)surrogate

eNOS activation is critical for regulating microcirculatory endothelial barrier function and vascular leakage during acute inflammation in vivo.

Cite This Study

Bucci et al. (2005) studied this question.

synapsesocial.com/papers/6a75978920ccc22d0a67a665https://doi.org/10.1073/pnas.0408906102
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of nitric oxide synthase inhibitors on endothelial [Ca2+]i and microvessel permeability1997 · 55 citations
  2. 2Phosphorylation and subcellular translocation of endothelial nitric oxide synthase.1993 · 325 citations
  3. 3Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability2001 · 1,028 citations
  4. 4Enhanced Release of Prostaglandins Contributes to Flow-Induced Arteriolar Dilation in eNOS Knockout Mice1999 · 185 citations
  5. 5In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF2000 · 138 citations