What question did this study set out to answer?

To describe the clinical manifestations, neuroimaging characteristics, therapeutic management, and outcomes of children diagnosed with acute necrotizing encephalopathy.

October 9, 2020Frontiers in PediatricsOpen Access

Acute Necrotizing Encephalopathy of Childhood: A Multicenter Experience in Saudi Arabia

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Authors

FBFahad A. BashiriKing Saud Medical City SJSultan Al JohaniKing Saud University MHMuddathir H. HamadKing Saud Medical City

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Implication

Retrospective multicenter study reveals variable clinical outcomes and 25% mortality in pediatric acute necrotizing encephalopathy, highlighting the potential benefit of early immunotherapy.

Key Points

To describe the clinical manifestations, neuroimaging characteristics, therapeutic management, and outcomes of children diagnosed with acute necrotizing encephalopathy.
Conducted a retrospective chart review of pediatric patients with acute necrotizing encephalopathy across five tertiary care centers in Saudi Arabia between January 2015 and October 2018 (N=12; age range: 10 months to 6 years).
Evaluated presenting clinical features, magnetic resonance imaging findings, medical interventions, and neurological outcomes.
All 12 patients presented with preceding febrile illness, depressed consciousness, and seizures, with 100% displaying characteristic thalamic neuroimaging abnormalities and 41.7% (n=5) showing brainstem involvement.
All patients received empirical antibiotics and antivirals, while 83.3% (n=10) were treated with intravenous immunoglobulin and intravenous methylprednisolone.
Patient outcomes ranged from full recovery with minimal deficits to death, yielding an overall mortality rate of 25.0% (n=3).

Cite This Study

Bashiri et al. (2020) studied this question.

synapsesocial.com/papers/6a759814d17bc701ee160fdc https://doi.org/10.3389/fped.2020.00526

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Implication

Retrospective multicenter study reveals variable clinical outcomes and 25% mortality in pediatric acute necrotizing encephalopathy, highlighting the potential benefit of early immunotherapy.

Acute Necrotizing Encephalopathy of Childhood: A Multicenter Experience in Saudi Arabia

Discussion

Member takes

Implication

Key Points

Cite This Study

Acute Necrotizing Encephalopathy of Childhood: A Multicenter Experience in Saudi Arabia

Discussion

Member takes

Implication

Key Points

Cite This Study

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