Key result
Age <48 months in acute necrotizing encephalopathy is linked to a ~100% neurodeficit rate.
Population
19 children diagnosed with ANEC over 9 years at a single center from south India
Design
Single-center retrospective case series
Authors
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Adds single-center ANEC data in children; leaves open optimal management and outcomes.
Observational (n=19)
No
Absolute Event Rate: 100% vs 11.1%
p-value: p=0.018
In a case series of children with ANEC, younger age (<48 months) was significantly associated with persistent neurodeficits at follow-up.
Gupta et al. (2021) conducted an observational in Acute necrotizing encephalopathy of childhood (ANEC) (n=19). Age <48 months vs. Age >48 months was evaluated on Neurodeficits at follow-up (p=0.018). Age <48 months in children with acute necrotizing encephalopathy was associated with a 100% rate of neurodeficits at follow-up compared to 11.1% in those aged >48 months (P=0.018).
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