Resistance of bacterial biofilms to antibiotics a growth-rate related effect?

Michael R. Brown; David Allison; Peter Gilbert

doi:10.1093/jac/22.6.777

January 1, 1988Journal of Antimicrobial ChemotherapyOpen Access

Resistance of bacterial biofilms to antibiotics a growth-rate related effect?

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Key Points

To evaluate whether the heightened antibiotic resistance observed in bacterial biofilms is primarily driven by alterations in bacterial growth rates.
Literature and mechanistic review evaluating antimicrobial susceptibility in surface-associated bacterial communities compared to planktonic cells.
Analysis of bacterial physiology, nutrient limitation gradients, and replication kinetics within biofilm architectures.
Highlights that slow growth and nutrient depletion within biofilms significantly diminish the efficacy of growth-dependent antibiotics.
Suggests physiological changes linked to reduced division rates contribute more to biofilm survival than conventional acquired genetic resistance mechanisms.

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Implication

Scientific review investigates antibiotic resistance in bacterial biofilms, suggesting reduced growth rates drive phenotypic tolerance.

Abstract

MICHAEL R. W. BROWN, DAVID G. ALLISON, PETER GILBERT; Resistance of bacterial biofilms to antibiotics a growth-rate related effect?, Journal of Antimicrobial Ch

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Brown et al. (1988) studied this question.

synapsesocial.com/papers/6a7599553e2789f4c260003b https://doi.org/10.1093/jac/22.6.777

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Resistance of bacterial biofilms to antibiotics a growth-rate related effect?

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Resistance of bacterial biofilms to antibiotics a growth-rate related effect?

Key Points

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Abstract

Discussion

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